Expert Details
Organic and Medicinal Chemistry
ID: 731252
Florida, USA
compounds using various NMR techniques 1-D and 2-D (COSY, HMBC, TOCSY, ROESY) diverse analytic techniques for compounds purification, use of various chemistry software
applications, databases for bibliography and patent searching.
Additionally, Expert has experience in Intellectual Property, Patent Searching and Analysis in Organic, Medicinal,Pharmaceutical, and Agricultural Organic Chemistry.
His greatest strengths and assets to any company, organism, are characterized by his polyvalence, experiences with various classes of compounds that allow me to simultaneously
to work on various projects, strong will to strive for excellence, good team player, and great motivation to acquiring knowledge, flexibility, and desire to reach common goals for a
company. His other main assets to any company, organization, are his international experiences, multilingual skills, to travel for any company for international tasks and representing
a company in international symposium.
Key areas of expertise include:
•. Natural Product Synthesis and Characterization • Carbohydrates and Glycoconjugates
• Heterocyclic Compounds • Parallel Synthesis, Small Molecules
• Organo-Metallic in Organic Synthesis • Peptides and Peptidomimetics Chemistry
• Consulting • Patent Searching & Analysis
TECHNICAL AND SCIENTIFIC PROFILE
Several years of experience in synthetic methodology, multi-step synthesis, optimization of reaction conditions towards small to large scale synthesis of natural compounds that
have application to SAR, Bio- Conjugation, Biopharmaceutical, as well as Agricultural Chemistry applications.
Experience in Process Chemistry, Process Optimization, and Generation Process Data, worked in clean GMP Laboratory
In medium large and large scale of diverse monosaccharides, small molecules for preparation of large glycoconjugates.
Several years’ of experience in manipulating air sensitive compounds, including synthesis of various compounds, and organophosphorous compounds. Experienced in using
organosilicon, transition organo-metallic elements (Rhodium, Cobalt, and Palladium) for synthesis of various natural products.
Achieved parallel synthesis of various natural products, carbohydrates, and glycoconjugates.
Achieved, elaborated, and conceived synthetic methodology for construction of difficult glycosidic bonds present in many natural compounds, such as Saponins, Glyco-
Anthracyclines and various other glycoconjugates that display interesting biological activities as anti-cancer, anti-cardiac agents.
Four years’ experience Medicinal Chemistry Consultant for developing and devising new efficient synthetic schemes to for anti-cancer, antiviral agents, such as small molecules for
oncology, various classes of heterocyclic compounds, complex intermediates for natural products, peptidomimetics, carbohydrates, asymmetric synthesis of bioactive compounds
that are to be carried out in company’s laboratory. Experience in amino acids derivatives synthesis, solution, solid phase, synthesis of peptides and peptidomimetics.
Localities: Expert wish and very opened to consult nationally and internationally in USA, (all States), Canada ( All Provinces), European Union Countries, Scandinavian
Countries,Israel, Panama, Costa Rica, Brazil, Qatar, Dubai, Japan, Singapore, Taiwan, Australia.
Achieved multi-step synthesis of natural product synthesis of cyclic compounds such as terpene, sesquiterpene, C-C bond formation, asymmetric synthesis of small molecules,
natural products, synthesis of heterocyclic compounds, lipids, glycolipids, and glyco- amino lipids compounds. Achieved synthesis of complex cyclic acetogenins as pesticides and
fungicides for crop protection, cross methathesis reactions, coupling and cyclization reactions with palladium complexes.
Several years’ of experience in manipulating air sensitive compounds, including synthesis of various compounds, and organophosphorous compounds. Experienced in using
organosilicon, transition organo-metallic elements (Rhodium, Cobalt, and Palladium) for synthesis of various natural products.
Achieved parallel synthesis of various natural products.
ANALYTICAL AND COMPUTER SKILLS
More than ten years’ experience in characterization of compounds by using 1D-NMR, 2D-NMR (H-H COSY, C-H COSY, HMBC, TOCSY, ROESY, etc.), Mass, IR-UV spectroscopy.
Many years’ experience in techniques of purification and separation by analytical and preparative HPLC, Standard and Reverse Phase Chromatography, Flash Chromatography, GC-
MS, LC-MS
Several year of experience and knowledge in the utilization of chemistry search program soft wares such as Sci-Finder, Reaxys, File Registry Chemical drawings (STN) and CAPLUS
File Registry, Chemsketch, Chemwindows, Chemdraw, NMR-programs to retrieve and process 1 -and 2 –dimensional NMR spectrums. Others: PowerPoint, MS-Word, Word Perfect,
Excel, Windows 1998, 2000, 2003-2007. Knowledge of numerous software search programs for patent examining, East, West, AOCS, and Dialogue, also extremely helpful for
bibliographical chemical searches pertaining to scientific research.
He provide consulting services in developing and devising new efficient synthetic schemes to for anti-cancer, antiviral agents, such as small molecules for oncology, various heterocyclic compounds, complex intermediates for natural products, peptidomimetics, carbohydrates, asymmetric synthesis of bioactive compounds that are to be carried out in company’s laboratory. Characterization analysis of compounds by using 1D-NMR, 2D-NMR), GC-LC-MS, MS, IR-UV spectroscopy.
He conceived and advised on efficient short synthetic routes of various nitrogen heterocyclic compounds such as oxazole, imidazol,oxadiazole, thiazole compounds and analogues, 1-H-Thiazolo [3,4-a] Quinazolin-One Analogues. Most of these compounds inhibit medicinal biological activities such as anti-cancer, anti-viral, and anti-aids agents. Synthesis on Spiro[Pyrrolidine 3,2, ]-4,5-Dihydrothiemo-[2,3-b] Thiophene-2-Sulfonamides Analogues as Carbonic Inhibitors for treatment of Glaucoma, and Ocular Hypertension. All to be carried out in laboratory synthetic procedures.
Advised on characterization analysis of compounds by using 1D-NMR, 2D-NMR), GC-LC-MS, and HPLC, reversed and chiral HPLC purifications and seperarion of isomers, and impurities.He devised, and advised best synthetic routes for Benzodiazepines, Heterocyclic Alkaloids, such s Pyrazole Alkaloids, Indole Alkaloids, Quinolein and Isoquinoleine Alkaloids, Quinazoline and Quinolidine Alkaloids, Steroids Alkaloids, Peptide Alkaloids, and other classes of Alkaloids compounds, to be carried out in laboratory synthetic procedures.
Advised on characterization analysis of compounds by using 1D-NMR, 2D-NMR), GC-LC-MS, and HPLC, reversed and chiral HPLC purifications and seperarion of isomers, and impurities.
He devised synthesis of Carbohydrates and Glycoconjugates such as Trisaccharides, Pentasaccharides, and Glyconjugates such as various Saponins, (combination of sugars with Steroids, Terpenes, and Triterpenes). Peptides and Pepdidomimetics, Cyclopeptides and Cyclopeptidomimetic Synthesis. Synthesis of O-(2-Acetamido-2-Deoxygalactosyl) Tyrosine Analogues, Synthesis of Chlorogenic Acid-Based Cyclopeptidomimetics as anti-fungal agents, Synthesis of
Cyclo-Modified Peptides using Alpha-Sugar Amino Acids Based Cyclic Peptides.
Advised on characterization analysis of compounds by using 1D-NMR, 2D-NMR), GC-LC-MS, and HPLC, reversed and chiral HPLC purifications and seperarion of isomers, and impurities.He conceived, and advised on mult-step synthetic routes using asymmetric synthesis of intermediate complex Natural Products, Enantiomeric Synthesis of Natural and Unnatural Amino Acids, and Synthesis of Enantiomeric Peptides. Synthetic routes for production of Steroids, Terpenes and Triterpenes to be combined with different carbohydrates for formation of different glycoconjugates, and carried out in laboratory synthetic procedures.
Advised on characterization analysis of compounds by using 1D-NMR, 2D-NMR), GC-LC-MS, and HPLC, reversed and chiral HPLC purifications and seperarion of isomers, and impurities.
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 2005 | Degree: PhD. | Subject: Organic Chemistry | Institution: Institute of Organic Chemistry, Eberhard- Karls – Universität Tübingen , Tübingen, Germany |
| Year: 1991 | Degree: Masters of Science | Subject: Organic Chemistry | Institution: University Paul Sabatier |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 2010 to Present | Employer: Undisclosed | Title: Medicinal and Organic Chemistry Consultant | Department: Medicinal Chemistry |
Responsibilities:Four years’ experience Medicinal Chemistry Consultant for developing and devising new efficient synthetic schemes to for anti-cancer, antiviral agents, such as small molecules for oncology, various classes of heterocyclic compounds, complex intermediates for natural products, peptidomimetics, carbohydrates, glycoconjugates,asymmetric synthesis of bioactive compounds that are to be carried out in company’s laboratory. |
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| Years | Employer | Title | Department |
| Years: 2006 to 2008 | Employer: National Institute of Health | Title: Post-Doctoral Research Scientist | Department: National Institute of Child Health & Human Development, (NICHD) |
Responsibilities:Research project focused on the synthesis and development of polysaccharides and lipido-aminoacids adjuvant and the combination of these adjuvants with a short saccharide or large polysaccharide to construct a glyco-amino lipid derivative.Synthesis of monosaccharides in medium-large and large scale synthesis in clean GMP room laboratory, to construct oligosaccharides linkage of glycoamino-lipids to a carrier protein in order to stimulate cellular immune defense. Process optimization and generation of process data was also performed in GMP Clean Room Laboratory. Characterization of compounds by using 1D-NMR, 2D-NMR), GC-LC-MS, MS, IR-UV spectroscopy. Purification and separation of compounds by analytical and preparative HPLC, Standard and Reverse Phase Chromatography, Flash Chromatography |
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| Years | Employer | Title | Department |
| Years: 2000 to 2005 | Employer: Eberhard- Karls – Universität Tübingen,Institute of Organic Chemistry | Title: Research Associate Scientist & Adjunct Laboratory Professor | Department: Institute of Organic Chemistry |
Responsibilities:Developed and devised the total stereo and region-selective synthesis of cyclic disaccharides by Intramolecular Glycosylation, an efficient methodology to create difficult glycoside linkages present in natural glycoconjugates; unachievable by the conventional glycosylation method. The cyclic products can be transformed into Saponins, large classes of glycoconjugates that bears terpepnes, triterpenes, steroids.Efficient synthetic method for production and construction polysaccharide vaccines, various glycoconjugates, and dendrimers of medicinal importance. Applications to SAR, and Bioconjugation, Pharmaceutical applications. Purification and separation of compounds by analytical and preparative HPLC, Standard and Reverse Phase Chromatography, Flash Chromatography.Characterization of compounds by using 1D-NMR, 2D-NMR (H-H COSY, C-H COSY, HMBC, TOCSY, ROESY, etc.), GC-LC-MS, MS, IR-UV spectroscopy |
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| Years | Employer | Title | Department |
| Years: 2001 to 2005 | Employer: Eberhard- Karls – Universität Tübingen | Title: Adjunct Laboratory Professor | Department: Institute of Organic Chemistry |
Responsibilities:Five years’ experience as group leader in lecturing and assisting graduate and undergraduate of German candidates as well as candidates of diverse nationalities, ethnic background in laboratory experiments in General, Organic and Advanced Organic Chemistry. Experienced mentoring and providing guidance Master’s and Bachelor’s degree candidates insights in their laboratory research projects experiments, assisting them in using recent chemical analytical instrumentations including writing their diploma’s thesis. Experienced in preparing written, oral examinations, as well as grading examinations and laboratory reports for undergraduates and graduate candidates.Managed laboratory instruments, material resources in chemicals that are reagents, solvents, acids, bases for to ensure carrying experiments in a continuous flow.Managed laboratory safety by teaching and advising candidates the use of flammable solvents, acids, bases.Coordination for budget management of our laboratory for new computer software, analytic instrumentation,new chemicals, management of laboratory spending, coordinate invitation specialist from corporation to hold seminar regarding the use of most recent analytical instruments. |
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Government Experience
| Years | Agency | Role | Description |
|---|---|---|---|
| Years: 2006 to 2008 | Agency: National Institute of Health | Role: Post-Doctoral Research Scientist | Description: Research project focused on the synthesis and development of polysaccharides and lipido-aminoacids adjuvant and the combination of these adjuvants with a short saccharide or large polysaccharide to construct a glyco-amino lipid derivative Synthesis of monosaccharides in medium-large and large scale synthesis in clean GMP room laboratory, to construct oligosaccharides linkage of glycoamino-lipids to a carrier protein in order to stimulate cellular immune defense. Process optimization and generation of process data was also performed in GMP Clean Room Laboratory |
| Years: 2008 to 2008 | Agency: US Patent & Trademark Office | Role: Scientific Patent Examiner | Description: Patent examiner in Organic Chemistry, Biotech, Pharmaceuticals. Skills of patent examining applications, inventions, search of prior art by using multiple scientific and patent search software toward finding prior art. Use of scientific specialty to determine prior art, patentability or non-patentability of organic chemistry inventions pertaining to Biotech-Pharma. Characterization analysis of compounds by using 1D-NMR, 2D-NMR), Mass, IR-UV spectroscopy when spectrum are demanded by patent examiner |
International Experience
| Years | Country / Region | Summary |
|---|---|---|
| Years: 2000 to 2005 | Country / Region: Tuebingen, Germany | Summary: Expert occupied a Research Associate and Adjunct Professor Position at Eberhard-Karl University of Tuebingen, located in Tuebingen, Germany, where his Doctoral Research project embraced, Carbohydrate & Glycoconjugate Chemistry. He also lectured General, Organic and Advanced Organic Chemistry in German language at graduate and undergraduate level, mentored Master's Degree candidates in their laboratory project, assisted Graduate and undergraduates in synthesis, compounds characterization,and purification techniques. Furthermore, as an Adjunct Laboratory professor during his 5 years of Doctoral Candidacy, at Eberhard-Karl-University of Tuebingen in Germany, Expert acquired five years’ experience as group leader in lecturing and assisting graduate and undergraduate candidates of diverse nationalities, ethnic background in laboratory experiments in General, Organic and Advanced Organic Chemistry. He mentored and provided guidance to Master’s and Bachelor’s degree candidates in their laboratory research projects experiments, assisting them in using recent chemical analytic instrumentation, including writing their diploma’s thesis. Additionally he prepared written, oral examinations, as well as graded examinations and laboratory reports for undergraduates and graduate candidates. Managed laboratory instruments, material resources in chemicals that are reagents, solvents, acids, bases for to ensure carrying experiments in a continuous flow. Managed laboratory safety by teaching and advising candidates the use of flammable solvents, acids, bases. Coordination for budget management of our laboratory for new computer software, analytic instrumentation, new chemicals, management of laboratory spending, coordinate invitation specialist from corporation to hold seminar regarding the use of most recent analytic instruments. |
| Years: 1988 to 1991 | Country / Region: Toulouse, France | Summary: Expert resided 7 years in France, where he enrolled at, University Paul Sabatier, Toulouse, France where he carried research in Organo-Metallic Chemistry at Centre National de Recherche Scientifique,(CNRS) which is the equivalent of Max-Plank Institutes in Germany and earned his Master's Degree in Organic Chemistry. Additionally, Expert pursued his Master's Degree Research Project at the Universite de Science te Technique de Languedoc, in Montpellier, France at Centre National de la Recherche Scientifique in Synthesis of Thiazole and Thiazoline Dipeptides and Tripeptides (Peptidomimetics)for |
| Years: 1992 to 1993 | Country / Region: Lausanne, Switzerland | Summary: After earning his Master's Degree, Expert enrolled for a year in Lausanne Switzerland, where he occupied a Research Associate Organic Chemist Position in Peptides and Peptidomimetics at Institute of Organic Chemistry, Universite de Lausanne, Switzerland. |
Additional Experience
| Expert Witness Experience |
|---|
| No litigation held |
| Training / Seminars |
|---|
| He held frequently bi-monthly group seminar in presence of Faculty Members, Industrial Scientist, and Research Scientist Colleges in Academia and Industry Attended National Symposiums, and International Symposiums Training of undergraduate and Graduates: Mentoring, assisting undergraduates and graduates in General, Organic and Advanced Organic Chemistry Laboratory and recitation sessions. Mentoring Master’s and Advanced Bachelor’s Degree candidates in discussing eventual new scientific approaches for their Degree Research Projects such as Synthetic Organic Chemistry Strategies, assisting them in the use of various analytical instrumentations for structural characterization (NMR, UV, IR), including purification and separation techniques. Assistance in NMR analysis 1and 2-Dimentional NMR, UV, and IR for compound characterization. Mentoring graduates and undergraduates in their Thesis writing, correcting laboratory reports |
| Other Relevant Experience |
|---|
ANALYTIC AND COMPUTER SKILLS More than ten years’ experience in characterization of compounds by using 1D-NMR, 2D-NMR (H-H COSY, C-H COSY, HMBC, TOCSY, ROESY, etc.), Mass, IR-UV spectroscopy. Many years’ experience in techniques of purification and separation by analytic and preparative HPLC, Standard and Reverse Phase Chromatography, Flash Chromatography. Several year of experience and knowledge in the utilization of chemistry search program soft wares such as Sci-Finder, Reaxys, File Registry Chemical drawings (STN) and CAPLUS File Registry, Chemsketch, Chemwindows, Chemdraw, NMR-programs to retrieve and process 1 -and 2 –dimensional NMR spectrums. Others: PowerPoint, MS-Word, Word Perfect, Excel, Windows 1998, 2000, 2003-2007. Knowledge of numerous software search programs for patent examining, East, West, AOCS, and Dialogue, also extremely helpful for bibliographical chemical searches pertaining to scientific resea LINGUISTIC SKILLS Full fluency in English, French, German, working knowledge of Spanish, Italian, Portuguese. Performs scientific article translation German-English, French-English and English-to French- and to German Leadership and Management Skills: Five years’ experience as group leader in lecturing and assisting graduate and undergraduate candidates of diverse nationalities, ethnic background in laboratory experiments in General, Organic and Advanced Organic Chemistry. Experienced mentoring and providing guidance Master’s and Bachelor’s degree candidates insights in their laboratory research projects experiments, assisting them in using recent chemical analytic instrumentation including writing their diploma’s thesis. Experienced in preparing written, oral examinations, as well as grading examinations and laboratory reports for undergraduates and graduate candidates. Managed laboratory instruments, material resources in chemicals that are reagents, solvents, acids, bases for to ensure carrying experiments in a continuous flow. Managed laboratory safety by teaching and advising candidates the use of flammable solvents, acids, bases. Coordination for budget management of our laboratory for new computer software, analytic instrumentation, new chemicals, management of laboratory spending, coordinate invitation specialist from corporation to hold seminar regarding the use of most recent analytic instruments. |
Language Skills
| Language | Proficiency |
|---|---|
| English (not foreign language) | Doctor Expert was born in New York City where he resided half of his life, thus is very frequent in English. |
| French | He was born from French speaking parents and reside seven years in Belgium where he attended all his elementary school education. Furthermore, Expert resided 7 years in France, where he enrolled at an internationally the world known institution, University Paul Sabatier, Toulouse, France where he carried research in Organo-Metallic Chemistry at Centre National de Recherche Scientifique,(CNRS) which is the equivalent of Max-Plank Institutes in Germany and earned his Master's Degree in Organic Chemistry. Additionally, Expert pursued his Master's Degree Research Project at the Universite de Science te Technique de Languedoc, in Montpellier, France at Centre National de la Recherche Scientifique in Synthesis of Thiazole and Thiazoline Dipeptides and Tripeptides (Peptidomimetics)for production of Enatiomeric Cyclo-Thiazole Peptides as anti cancer agents. Furthermore he enrolled for a year in Lausanne Switzerland, where he occupied a Research Associate Organic Chemist Position in Peptides and Peptidomimetics at Institute of Organic Chemistry, Universite de Lausanne, Switzerland. |
| German | Expert occupied a Research Associate and Adjunct Professor Position at Eberhard-Karl University of Tuebingen, located in Tuebingen, Germany, where his Doctoral Research project embraced, Carbohydrate & Glycoconjugate Chemistry. He also lectured General, Organic and Advanced Organic Chemistry in German language at graduate and undergraduate level, mentored Master's Degree candidates in their laboratory project, assisted Graduate and undergraduates in synthesis, compound characterization,and purification techniques. Furthermore,he resided in the city of Basel, German part of Switzerland, where he worked as a Synthetic Organic Chemist in the Crop and Plant Division, (Agricultural-Chemistry. |
| Spanish, Italian, Portuguese | Expert partially reads, understands Spanish, Italian, Portuguese. He possesses good understanding of chemical scientific articles in all three languages, with the ability to translate them in English. |
Fields of Expertise
aldehyde, allyl compound, amino acid, aromatic compound, aromatic compound synthesis, asymmetric synthesis, carbanion chemistry, carbocation chemistry, carbohydrate, carbohydrate analysis, carbohydrate chemistry, carbohydrate low-pressure preparative liquid chromatography, carbohydrate nuclear magnetic resonance spectroscopy, carbohydrate synthesis, carbohydrate synthesis blocking strategy, chemical intermediate, chemical reaction mechanism, chlorinated organic compound, chromatography applications, complex carbohydrate synthesis, cyclic compound, disaccharide, epoxy compound, fine chemical, fine organic synthesis, flash chromatography, furan, furanose, furazosin, glycolipid, glycopeptide, glycoside, glycosylation, Grignard synthesis, heterocyclic chemistry, heterocyclic compound, heterocyclic compound synthesis, hydroxyl group, imidazole, indole, lipopolysaccharide, liquid chromatography, macrocyclic substituted heterocyclic compound, monomer, monosaccharide, mucopolysaccharidosis, natural organic compound, natural product, natural product chemistry, nitrogen heterocyclic compound, nuclear magnetic resonance spectroscopy, oligosaccharide, oligosaccharide chemistry, oligosaccharide nuclear magnetic resonance spectroscopy, oligosaccharide synthesis, organic carbonate compound, organic chemistry, organic compound, organic synthesis, organohalogen, organometallic compound, organosilicon, oxazole, peptide, peptide coupling, piperidine, plant natural product, polysaccharide, procedure, purine, pyrazine, pyrazole, pyridine, pyrimidine, quinoline, small-ring substituted heterocyclic compound, substituted heterocyclic compound, sulfur heterocyclic compound, extraction, ketone, lipid, organic compound manufacturing, organolithium, organomercury compound, synthetic organic chemistry, terpene synthesis