Expert Details

Mitochondrial DNA Stability, Oxidative Stress, Metabolism

ID: 731532 Pennsylvania, USA

Expert is an Assistant Professor at Employer studying mechanisms that regulate mitochondrial DNA stability, which is of broad medical relevance, including aging, diabetes, liver disease, heart disease, and cancer. Expert's laboratory has published in Nucleic Acids Research, Nature Cell Biology, and Pos ONE. During Ph.D. research, Expert performed the seminal characterization of proteins involved in mitochondrial DNA metabolism, which was published in Proceedings of the National Academy of Science, Science, Journal of Cell Biology, and Methods in Molecular Biology. He went on to work with Dr. Eric Shoubridge at McGill University, where he discovered the primary mechanisms of compaction and organization of mammalian mtDNA and contributed to the study of understanding respiratory disorder etiology, publishing in Molecular Biology of the Cell, Cell Metabolism, and Human Molecular Genetics, and Nature Genetics. In total, he has over 17 years experience in working with mitochondria and mtDNA interacting proteins. He is active in the Mitochondrial Research Affinity Group and Center for Mitochondrial and Epigenomic Medicine at UPENN.

He has provided feedback on therapeutic opportunities in mitochondria regarding potential drug targets

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Education

Year	Degree	Subject	Institution
Year: 2003	Degree: PhD	Subject: Cell and Molecular Biology	Institution: University of Texas Southwestern Medical Center at Dallas
Year: 1995	Degree: BS	Subject: Biochemistry	Institution: Indiana University

Work History

Years	Employer	Title	Department
Years: 2009 to Present	Employer: Undisclosed	Title: Assistant Professor	Department: Animal Biology
Responsibilities: Spearheaded efforts to understand the etiology of common and rare disorders, including the identification of novel disease mechanisms. Contributed during all phases of progression of high-impact research projects for multiple groups. Lead efforts to identify alleles from large human exome datasets that potentially confer vulnerability or cause disease with direct relevance to mitochondrial, cardiovascular, diabetes, cancer and age-related diseases. Taught graduate level biochemistry lecture and lab for four years. Raised $1.3M in research support. Supervised 2 post-doctoral fellows, 2 graduate students, 2 veterinary students, 3 technicians, and 10 undergraduates. Served on faculty search, judicial, and conference planning committees and co-organized lecture series. Published 4 papers in Nucleic Acids Research, Nature Cell Biology, Biochemica Biophysica Acta and PLoS ONE, with numerous more in preparation and submission.
Years	Employer	Title	Department
Years: 2003 to 2008	Employer: McGill University	Title: Postdoctoral Fellow	Department: Montreal Neurological Institute
Responsibilities: Independently developed research program that identified the primary mechanism of mitochondrial DNA packaging while contributing biochemical expertise to the study of mitochondrial respiratory complex assembly in patients. Published 4 papers in Molecular Biology of the Cell, Cell Metabolism, Human Molecular Genetics and Nature Genetics.

Career Accomplishments

Associations / Societies
ASCB, MDA, AHA, UMDF, Mitochondrial Society

Awards / Recognition
United Mitochondrial Disease foundation Chairman's Prize

Publications and Patents Summary
He has 13 publications

Fields of Expertise

mitochondrion, DNA, respiration, Southern blotting, molecular biology, DNA damage, organelle, cellular respiration, biological oxidation, drug-induced mitochondrial damage, mitochondrial damage, DNA synthesis, DNA structure, cell (biology), nucleic acid, DNA analysis, cell physiology