Expert Details
Membrane Traffic
ID: 107807
Texas, USA
HYBRID TOXINS; IMMUNOTOXINS. The goal of Expert's work with protein toxins is the construction of more potent and specific hybrid immunotoxins that may have chemotherapeutic value. He and his colleagues have applied to patent an approach in this area using toxins based on Pseudomonas aeruginosa exotoxin A.
ENDOCYTOSIS. Expert has done extensive work on the endocytosis of protein toxins and on the endocytosis of transferrin and the transferrin receptor. He has also worked a great deal on mammalian cells expressing genetic defects in the endocytic pathway.
SECRETION. Over the last four years, Expert has studied secretion as it relates to mutants he has isolated that are defective in the secretory pathway.
PSEUDOMONAS AERUGINOSA EXOTOXIN A. For the last five years, Expert has been studying the molecular and cellular biology of the Pseudomonas aeruginosa extoxin A, especially ways to improve immunotoxins made with exotoxin A. He and his colleagues submitted a patent application covering some of this work.
DIPHTHERIA TOXIN. Although the diphtheria toxin is not currently his focus, Expert has had a lot of experience with this toxin in the past and continues to follow the literature in the field.
Education
Year | Degree | Subject | Institution |
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Year: 1974 | Degree: PhD | Subject: Biological Chemistry | Institution: UCLA |
Year: 1968 | Degree: BA | Subject: Chemistry | Institution: University of Washington - Seattle |
Work History
Years | Employer | Title | Department |
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Years: 1980 to 2000 | Employer: UNIVERSITY OF TEXAS - DALLAS | Title: PROFESSOR OF BIOLOGY | Department: |
Responsibilities:Available upon request. |
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Years | Employer | Title | Department |
Years: 1974 to 1980 | Employer: | Title: Various postdoctoral fellowships | Department: |
Responsibilities:Available upon request. |
Career Accomplishments
Associations / Societies |
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Expert is a member of the American Society of Cell Biology and the American Association for the Advancement of Science. |
Publications and Patents Summary |
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Expert has over thirty published research articles and reviews in his fields of expertise. |
Fields of Expertise
cancer chemotherapeutic agent, cell anatomy, cell culture, cell membrane transport, cell physiology, cell surface interaction, diphtheria, endocytosis, hybrid toxin, immunotoxicology, immunotoxin, receptor-mediated endocytosis, Pseudomonas aeruginosa, diphtheria toxin, Pseudomonas, biologic cellular component, toxin, tissue culture, exotoxin, cellular signal transduction, antigen-antibody interaction