Expert Details
Bone Biology, Advanced Microscopy, 3D Imaging Analysis
ID: 728760
United Kingdom
Expert recently developed novel advanced 3D microscopy protocols to acquire images of large volumes of tissue (tiledZ stacks) which may be applied to any bone cancer preclinical model with fluorescent tags (for example myeloma, breast and prostate cancers). This permits quantitative analysis of cubic millimeters of tissue whilst maintaining single cell sensitivity. Expert is applying this method to locate early colonising cancer cells in the bone microenvironment and characterise the pre-metastatic and post-metastatic niche. To complement this Expert also developed a very high resolution microCT protocol to enable previously unknown tiny skeletal structures in murine skulls to be analysed. This has been successfully applied to assess the effects of bisphosphonates and other bone modulating therapeutics in a preclinical model and represent a putative pre-metastatic niche.
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 2007 | Degree: PhD | Subject: Bone Biology | Institution: Imperial College London, UK |
| Year: 1998 | Degree: MSc | Subject: Medical Biotechnology | Institution: Newcastle University, UK |
| Year: 1996 | Degree: BSc | Subject: Biochemistry | Institution: Newcastle University, UK |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 2007 to 2010 | Employer: University of Sheffield, UK | Title: Research Associate | Department: |
Responsibilities:Supervision of MSc and PhD students. Project grant member - characterising a cancer niche. |
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| Years | Employer | Title | Department |
| Years: 2002 to 2007 | Employer: Imperial College London, UK | Title: Research Associate | Department: |
Responsibilities:Teaching all new staff, PhD project, Laboratory protocol developments |
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| Years | Employer | Title | Department |
| Years: 1998 to 2002 | Employer: Newcastle University, UK | Title: Junior Research Associate | Department: |
Responsibilities:Laboratory duties. Developing an anti-OPG antibody. |
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Additional Experience
| Training / Seminars |
|---|
| Microscopy training - advanced, multiphoton, fluorescence, second harmonics. 3D analysis, proximity analysis. In vivo protocols teaching. |
| Marketing Experience |
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| With new techonology applications in imaging the future of cancer research is charactersing the early events permitting growth. |
| Other Relevant Experience |
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| He has developed a wide experience in bone biology and have specialised in orthopaedics, endocrinology and bone cancer. |