Expert Details
Biomedical Sciences, Vascular Biology, Angiogenesis
ID: 729028
United Kingdom
In that year he discovered the anti-angiogenic class of VEGF splice variants, and now investigates the potential of VEGF-splice variants, VEGF-induced angiogenesis and arteriogenesis, VEGF-receptor tyrosine kinase inhibitors, VEGF-activated ion channels and VEGF induced lymphatic metastasis. He discovered, with Jacqui Shields that melanomas can metastasise through recognising chemokines secreted from lymphatics (metastatic chemotaxis), and that this occurs through CCL21/CCR7 interactions. With Dr Neal, he discovered the sub-podocyte space of the kidney glomerulus, the first new urinary space in the kidney for 150 years. He was appointed Professor of Microvascular Biology and Medicine in the Department of Physiology and Pharmacology in Bristol.
Advising major pharmaceutical company on research, marketing and clincial applications of VEGF receptor tyrosine kinase inhibitor in cancer.Advising major pharmaceutical company on research, marketing and clinical applications of VEGF inhibitor in eye disease.Member of steering committee as the scientific expert for major drug company for clinical development of lead compound.
Education
Year | Degree | Subject | Institution |
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Year: 1992 | Degree: PhD | Subject: Physiology | Institution: University of London |
Year: 1989 | Degree: BSc | Subject: Zoology | Institution: University of Newcastle upon Tyne |
Work History
Years | Employer | Title | Department |
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Years: 2007 to Present | Employer: Undisclosed | Title: Undisclosed | Department: School of Physiology and Pharmacology |
Responsibilities:He is responsible for the academic, scientific, translational and educational progress of the Microvascular Research Laboratories within the School of Physiology and Pharmacology |
Career Accomplishments
Associations / Societies |
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British Microcirculation Society, The Microcirculatory Society, The European Microcirculation Society, The Physiological Society, The American Physiological Society. |
Awards / Recognition |
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Dr Hans and Mrs Gertrude Hirsch Award, Fight for Sight. British Heart Foundation Lectureship in Basic Biomedical Sciences (2006). Renewal of this highly competitive award to "non clinical researchers who have shown outstanding ability in carrying out original and independent research". Skin Cancer Research Fund 25th Anniversary Clinical Training Laboratory Award. The SCaRF awarded me £100,000 to help support research training for plastic surgeons in skin cancer. This was an ad hoc award to celebrate their 25th anniversary and was the only one of its kind made. Van Leeuwenhoek Outstanding Young Investigator Travel Award. European Society for Microcirculation. Christian Crone Outstanding Young Investigator Award, Microcirculatory Society. |
Publications and Patents Summary |
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104 published papers in peer reviewed journals, 1 patent awarded, 7 patent applications, four patents licensed. |
Additional Experience
Training / Seminars |
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Gordon Conference on Molecular Mechanisms of Lymphatic Disease International Advisory Committee; International Podocyte meeting. Organising committee; Experimental Biology, Anaheim. Featured topic organiser “Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators;” European Microcirculation Congress, Budapest, International Advisory Board; Gordon Conference on Molecular Mechanisms of Lymphatic Disease International Advisory Committee; World Congress on Microcirculation. Programme committee; European Vascular Biology Meeting. Organising committee; Experimental Biology, San Francisco. Regulation of glomerular filtration by the podocyte. Chair and Organiser; European Society for Microcirculation. Program committee; European Society for Microcirculation. Symposium organiser; Local Organising Committee, European Microcirculation Society meeting, Exeter, |
Marketing Experience |
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Invited Scientific Adviser to Global Experts Advisory Meeting for Pharmaceutical Industry partner. (Chicago, USA); Invited Scientific Adviser to Global Advisory Board for pharmaceutical company (New Orleans); Invited Scientific Adviser to pan-European Advisory Board of Retinal Specialists (Lisbon); Invited Scientific Adviser to UK pharmaceutical company Advisory Board. |
Fields of Expertise
angiogenesis, angiogenesis inhibitor, blood capillary, blood vessel, endothelial cell, endothelial cell biology, endothelium, malignant melanoma, myocardial revascularization, revascularization, skin tumor, vascular biology, vascular endothelial cell growth factor, diabetic retinopathy, macular degeneration, capillary permeability, kidney glomerulus, physiological process, blood flow meter, cancer physiology, antitumor drug, blood flow measurement, skin cancer, tumor biology, cancer, blood-brain transport, tumor, metastasis, vascular disease, cardiovascular disease, blood flow