Expert Details
Biomedical Sciences: Ageing Disorders, Cancer, Neurological Disorders, Molecular Cardiology, and Diabetes
ID: 738810
Florida, USA
Expert has engaged with Tegus as a Key Opinion Leader in the areas of cancer, neurobiology and cardiology for six months.
Expert's specialized scientific skills include RNA biology, molecular biology, stem-cell biology, cell biology, cancer biology, immunology, chromatin biology, and cardiac biology.
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 2003 | Degree: Ph.D | Subject: Biochemistry and Molecular Biology | Institution: University of California, San Diego |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 2018 to Present | Employer: Undisclosed | Title: Chief Scientific Officer | Department: R&D |
Responsibilities:RNA Enabling Theranostics -- the integration of therapeutics and diagnostics.- Big data analysis to identify common molecules in complex diseases - Validation of "unifying" small RNAs in disease - Optimization of High-throughput platform to identify disease-enriched proteins for theranostics Expert's work at her bioscientific firm includes: - In silico sequence analysis to identify highly penetrant “unifying” small RNAs as multi-target protein modulators in diseases (Cancer, T-cell function, Alzheimer’s, Autism) - Small RNAs as regulators of theranostics proteins including enzymes, cell-surface proteins and secreted proteins - “Unifying’ small RNAs and their interactomes as theranostics moieties |
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| Years | Employer | Title | Department |
| Years: 2019 to 2020 | Employer: University of South Florida | Title: General Faculty | Department: Heart Institute |
Responsibilities:Human iPS Modeling of Cardiomyopathies- iPS reprogramming from patient blood - Accelerated in vitro differentiation of human patient iPS to beating cardiomyocytes for cardiomyopathy disease-in-a-dish modeling (within weeks as opposed to decades in vivo) - Small RNA focused molecular mechanisms for cardiomyopathies and heart failure - Crosstalk between cardiac populations in cardiomyopathy progression |
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| Years | Employer | Title | Department |
| Years: 2017 to 2018 | Employer: University of South Florida | Title: Adjunct Faculty | Department: Heart Institute |
Responsibilities:RNA Delivery using Nanoparticles and Exosomes- Tumor Exosomes for Cardiac Regeneration - Development of cationic nanoparticles for RNA delivery |
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| Years | Employer | Title | Department |
| Years: 2016 to 2017 | Employer: University of South Florida | Title: Adjunct Faculty | Department: Molecular Medicine |
Responsibilities:RNA Modifications and Stemness in Cancer- Utilizing sphere assays and 3D tumoroid models to study contribution of small RNAs and RNA modifications to cancer stemness - Role of small RNAs in promoting cancer drug resistance and stemness - Drug screening for cancer stemness using sphere formation assays |
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| Years | Employer | Title | Department |
| Years: 2012 to 2014 | Employer: University of California, San Francisco | Title: Associate Specialist | Department: Biochemistry and Biophysics |
Responsibilities:Determination of Novel Functions for Non-Canonical small RNA's- Expert identified small RNA-protein interactions reflecting novel roles for small RNAs in transcriptional outcomes - Expert elucidated small RNA-RNA interactions as a putative mechanism for regulation of subcellular mRNA localization and downstream protein translation - Expert elucidated mechanisms by which telomerase dependent small RNAs could modulate proliferation/differentiation, chromatin states, drug resistance and OXPHOS - Expert identified small RNA-Protein interactions with therapeutic implications for cancer, diabetes, Alzheimer’s and chromatin imprinting |
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Additional Experience
| Expert Witness Experience |
|---|
| KOL for a primary research outfit since April 2022. |
Career Accomplishments
| Awards / Recognition |
|---|
| 1/5 Finalists PBMI Innovation Challenge to Reduce Drug Costs 1/15 winners, Brain Race, Administered by CAI and Brain Tumor Charity, UK Winner, VABeach Bio Challenge (Declined) T Semi-Finalist BioFlorida Semi-Finalist Founder, ThNA BioSciences Inc NSF/I-Corps Fellow, USF Shortlisted Candidate, Pfizer-IIT Delhi Innovation and IP Program Patent Filed (Patent No, US 12/496,481; Publication: US20100029501) Best Trainee Speaker Presentation, Cardiovascular Research Institute Meeting, UCSF Expert's biosciences firm has won the following awards: Center for Advancing Innovation (CAI) Brain Race VABeach Bio Challenge (Declined) Only Biotech Start-Up from Tampa Featured in BioFlorida Semi-Finalist USF BEAT, 2018 I-Corps, National Science Foundation, 2017 Finalist for the Pfizer-IIT Innovation Challenge, 2016 |
| Publications and Patents Summary |
|---|
| Expert has 10 publications related to cardiological health and/or RNA. She has also filed one patent related to a microRNA target screener. |
Fields of Expertise
cancer, cancer biology, cardiomyopathies, Alzheimer's disease, autism, biomarker, Parkinson disease, amyotrophic lateral sclerosis, Duchenne muscular dystrophy, muscular dystrophy, musculoskeletal disease, neuromuscular disorder, diabetes, exosomes, theranostics, drug resistance, cancer immunotherapy, stem cells, induced pluripotent stem cells, microRNAs, fibrosis, biomedical research and development