Expert Details

Cancer to Cardiovascular Research, Cardiovascular Biology, Tumor Biology, Technologies related to Cardiovascular Biology (research), Molecular Biology, Molecular Physiology

ID: 736050 Texas, USA

Expert received his Ph.D. in Cancer Biology in 2007 from the Center for Cellular and Molecular Biology in India. From 2007 to 2013, Expert acquired advanced scientific training as a postdoctoral fellow in the Division of Cardiology at University of Texas Southwestern Medical Center, where his research focused on cardiac and muscle disease. Expert was awarded a highly competitive American Heart Association (AHA) Postdoctoral Research Fellowship Grant (2009-2011) to fund his research. In addition, he was selected as a finalist for the 2010 Louis N. and Arnold M. Katz Basic Science Research Award, which is sponsored by AHA and represents the highest honor that can be bestowed upon a junior investigator. In February of 2013, Expert joined the cardiology research faculty at UT Southwestern Medical Center, where he led a team of researchers to perform cutting edge experimental research to discover novel pathways involved in the progression of heart and muscle disease.

Over the course of his academic training and career, Expert has acquired the ability to work across a diverse spectrum of research teams, both nationally and internationally, formulate data driven hypotheses to solve complex translational research problems and communicate the research findings in high impact publications. During his research career, Expert has gained an expertise in working with different disease models ranging from cancer, muscle, cardiovascular and metabolic diseases. He has also acquired significant experience in working with cutting edge research technologies such as high throughput sequencing, iPSCs and other stem cell technologies to identify molecular pathways in human patients of muscle and cardiac disease such as Duchenne Muscular Dystrophy.

Expert has more than 18 years of research experience across a wide variety of biomedical research models and has collaborated with world renowned experts in the field of cancer, cardiovascular disease, and metabolism.

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Education

Year	Degree	Subject	Institution
Year: 2020	Degree: MBA	Subject: Healthcare management	Institution: University of Texas at Dallas
Year: 2013	Degree: Diploma in Advanced Research (Postdoctoral Fellowship)	Subject: Molecular Cardiology	Institution: University of Texas Southwestern Medical Center
Year: 2008	Degree: PhD	Subject: Cellular and Molecular Biology	Institution: Centre for Cellular and Molecular Biology
Year: 2000	Degree: MS	Subject: Biochemistry	Institution: Hamdard University
Year: 1998	Degree: BS	Subject: Biochemistry	Institution: University of Delhi

Work History

Years	Employer	Title	Department
Years: 2019 to Present	Employer: Undisclosed	Title: Instrcutor	Department: School of LIfe Sciences
Responsibilities: Designing and administering course curriculum for undergraduate students. Classroom teaching with hands on laboratory exercises, designing and administering tests and exams in accordance with the university policy.
Years	Employer	Title	Department
Years: 2013 to 2018	Employer: University of Texas Southwestern Medical Center	Title: Instructor	Department: Internal Medicine/Cardiology
Responsibilities: As a faculty in the cardiology division of University of Texas Southwestern Medical Center at Dallas, I was engaged in performing cutting edge research to discover novel pathways involved in the progression of heart and muscle disease. The job responsibilities in this role included identifying high impact research question followed by designing and executing hypothesis driven research projects while leading a team of supporting research scientists, grant writing to secure research funding and research presentations at national and international meetings. In addition, I was involved in providing scientific training and intellectual feedback to senior research scientists, clinical research fellows and medical students in their respective projects. I was also responsible for managing research grant budget and ensuring research compliance for the projects under my supervision.

Career Accomplishments

Associations / Societies
Dates, Society Name, member 2007-present American Heart Association 2011-present American Association for Advancement of Science 2012-present Sigma Xi 2018-present American College of Healthcare Executives

Awards / Recognition
Year Name of Honor/Award Awarding Organization 2nd Place in the Annual Biochemistry Quiz. Delhi University; New Delhi, India Delhi University National Eligibility Test Scholarship, (Pre-doctoral Fellowship) Council of Scientific and Industrial Research (CSIR), India Best Poster Presentation at the Annual CCMB Open Day Centre for Cellular and Molecular Biology (CCMB); Hyderabad, India International Travel award Cold Spring Harbor Laboratory International Travel Grant Award CSIR and Department of Biotechnology (Government of India) South Central Postdoctoral Fellowship Award American Heart Association Young Investigator Travel Award American Heart Association Finalist: The Louis N. and Arnold M. Katz Basic Science Research Award American Heart Association Competitive Scholarship for the Full Time MBA Cohort University Of Texas at Dallas 3rd Place at the 10th International Emory Global Health Case Competition Emory University Colloquium for Advancement of Free Enterprise (CAFÉ) Graduate Fellowship University Of Texas at Dallas

Awards / Recognition

Year Name of Honor/Award Awarding Organization
2nd Place in the Annual Biochemistry Quiz. Delhi University; New Delhi, India Delhi University
National Eligibility Test Scholarship, (Pre-doctoral Fellowship) Council of Scientific and Industrial Research (CSIR), India
Best Poster Presentation at the Annual CCMB Open Day Centre for Cellular and Molecular Biology (CCMB); Hyderabad, India
International Travel award Cold Spring Harbor Laboratory
International Travel Grant Award CSIR and Department of Biotechnology (Government of India)
South Central Postdoctoral Fellowship Award American Heart Association
Young Investigator Travel Award American Heart Association
Finalist: The Louis N. and Arnold M. Katz Basic Science Research Award American Heart Association
Competitive Scholarship for the Full Time MBA Cohort University Of Texas at Dallas
3rd Place at the 10th International Emory Global Health Case Competition Emory University
Colloquium for Advancement of Free Enterprise (CAFÉ) Graduate Fellowship University Of Texas at Dallas

Publications and Patents Summary
1. The focus of my early research was on investigating the molecular mechanisms of apoptosis or programmed cell death. Several of the publications from my PhD research (2001-2006) addressed the molecular underpinnings of the mitochondrial apoptotic pathway in tumor cells. In 2001, apoptosis was a newly discovered pathway and the studies describing the mechanistic details of intracellular processes within an apoptotic cell were limited. My studies targeted at identifying differential gene expression in apoptotic cells led to the discovery of several novel genes that were shown to be critical in the execution of apoptosis. Specifically, I discovered that several subunits of the mitochondrial F0-F1 ATP synthase complex were upregulated during the early phases of apoptosis, resulting in increased ATP generation. In addition, I also identified a novel pro apoptotic role for the ubiquitin-proteasome machinery mediated by induction of the proteasome subunits’ gene expression. This body of work described, for the first time, several novel intracellular processes that are employed by the cell to successfully execute the apoptotic pathway. These studies discovered new distinguishing features of programmed cell death and shed new light on how the changes in gene expression are transformed into physiological events during apoptosis. I led majority of these studies in my capacity as the primary investigator or a co-investigator. 2. Cardiac remodeling in response to acute or chronic pathological stress is a complex and generally irreversible process. The genome wide expression changes and the resulting cross talk between molecular signaling components make it a challenge to identify new pathways that could be targeted to modulate left ventricular remodeling and subsequently modulate heart failure. My postdoctoral research focused on understanding the role of tissue globins (Cytoglobin and Myoglobin) in models of cardiac disease established the role of hypoxia and key regulatory factors in the transcriptional regulation of tissue globins. I also discovered novel roles of redox signaling in the regulation of cardiac hypertrophy via p53 modulation. These studies identified novel regulatory mechanisms governing cardiac remodeling during pathological or physiological hypertrophy and provided new targets for potential therapeutic intervention. I served as the primary investigator on these studies. 3. Skeletal myogenesis following acute muscle injury involves activation of myogenic progenitor cells (MPC) that contribute to the repair of injured muscle fibers by generating new myofibers and MPC self- renewal. The myogenic process is associated with oxidative stress but the redox factors and stress signals involved in regulating myogenesis following injury are not very well understood. As I transitioned to a junior faculty position, my research focused on investigating molecular mechanisms underlying skeletal muscle regeneration. I discovered a new redox sensitive protein that is critical for MPC viability and subsequent muscle regeneration in response to injury and reported its specific role in myoblast survival, proliferation and differentiation. These findings enhance our overall understanding of myogenesis and provide new information about the role of oxidative stress in muscle regeneration, which may enable the development of therapeutic approaches for treating patients with muscle injuries and other neuromuscular disorders. I served as the primary investigator on these studies.

Publications and Patents Summary

1. The focus of my early research was on investigating the molecular mechanisms of apoptosis or programmed cell death. Several of the publications from my PhD research (2001-2006) addressed the molecular underpinnings of the mitochondrial apoptotic pathway in tumor cells. In 2001, apoptosis was a newly discovered pathway and the studies describing the mechanistic details of intracellular processes within an apoptotic cell were limited. My studies targeted at identifying differential gene expression in apoptotic cells led to the discovery of several novel genes that were shown to be critical in the execution of apoptosis. Specifically, I discovered that several subunits of the mitochondrial F0-F1 ATP synthase complex were upregulated during the early phases of apoptosis, resulting in increased ATP generation. In addition, I also identified a novel pro apoptotic role for the ubiquitin-proteasome machinery mediated by induction of the proteasome subunits’ gene expression. This body of work described, for the first time, several novel intracellular processes that are employed by the cell to successfully execute the apoptotic pathway. These studies discovered new distinguishing features of programmed cell death and shed new light on how the changes in gene expression are transformed into physiological events during apoptosis. I led majority of these studies in my capacity as the primary investigator or a co-investigator.

2. Cardiac remodeling in response to acute or chronic pathological stress is a complex and generally irreversible process. The genome wide expression changes and the resulting cross talk between molecular signaling components make it a challenge to identify new pathways that could be targeted to modulate left ventricular remodeling and subsequently modulate heart failure. My postdoctoral research focused on understanding the role of tissue globins (Cytoglobin and Myoglobin) in models of cardiac disease established the role of hypoxia and key regulatory factors in the transcriptional regulation of tissue globins. I also discovered novel roles of redox signaling in the regulation of cardiac hypertrophy via p53 modulation. These studies identified novel regulatory mechanisms governing cardiac remodeling during pathological or physiological hypertrophy and provided new targets for potential therapeutic intervention. I served as the primary investigator on these studies.

3. Skeletal myogenesis following acute muscle injury involves activation of myogenic progenitor cells (MPC) that contribute to the repair of injured muscle fibers by generating new myofibers and MPC self- renewal. The myogenic process is associated with oxidative stress but the redox factors and stress signals involved in regulating myogenesis following injury are not very well understood. As I transitioned to a junior faculty position, my research focused on investigating molecular mechanisms underlying skeletal muscle regeneration. I discovered a new redox sensitive protein that is critical for MPC viability and subsequent muscle regeneration in response to injury and reported its specific role in myoblast survival, proliferation and differentiation. These findings enhance our overall understanding of myogenesis and provide new information about the role of oxidative stress in muscle regeneration, which may enable the development of therapeutic approaches for treating patients with muscle injuries and other neuromuscular disorders. I served as the primary investigator on these studies.

Fields of Expertise

appendiceal cancer, acute myocardial infarction, cardiomyopathies, cardiology, cardiopulmonary disease, cardiovascular abnormality, cardiovascular disease, cardiovascular research, cardiovascular drug therapy, cardiovascular pharmacology, cardiovascular system, antitumor drug, tumorigen, cancerous tumor, central nervous system tumor, brain tumor, gastrointestinal stromal tumor, lung tumor, tumor, tumor biology, tumor marker testing, tumor necrosis factor, tumor pathology, Duchenne muscular dystrophy, skeletal muscle physiology, musculoskeletal disease, muscular dystrophy, muscular disease, neuromuscular disorder, adverse drug effect, adverse drug reaction, antagonistic drug, anti-fibrotic drug, animal molecular biology, applied molecular biology, biologic (product), biological cell development, biological cell differentiation, biological drug level, apoptosis, cellular signal transduction, biomedical signal processing, cancer biology, cancer causation, cancer chemotherapeutic agent, breast cancer, cancer, cancer cytology, cancer immunotherapy, cancer research, cancer chemoprevention, cancer immunology, cancer pathology, cancer treatment, cancer physiology