Expert Details
Immunoreagents, Clinical Reagents, Surfactant Science
ID: 721986
New York, USA
He developed biological microemulsions by solubilizing high concentrations of lipids (cholesterol and tryglyceride). These formulations were optically-clear solutions, which were used as standards and controls in auto analyzers. He used surfactants to enhance the activity of antibodies in immunoassays. Under Expert’s direction, new surfactants were introduced to enhance the proteolytic enzyme activity for cholesterol/triglyceride reagents. He prepared a liposome formulation using a new surfactant to maintain the integrity of liposome in solutions.
He used surfactant-based formulations to clear lipemic serum samples.
Expert engineered a dry blend formulation for clinical reagents using solid surfactants. He has prepared cleansing solutions for wetting and cleaning surfaces such as glass, Teflon, Tygon, nylon and polymers. An array of surfactants was used to solubilize dyes, drugs and peptides. Expert prepared ancillary reagents using surfactants to maintain the integrity of blood components used in hematology, clinical and immuno-analyzers.
In association with others, Expert developed phase diagrams, theories of stability of emulsions, microemulsions, foams and electrostatic influences on dyes in surfactant solutions. He developed and modified immuno- and clinical reagents.
He has used various techniques, such as contact angles, surface/interfacial tension, viscosity, electrical potential measurement, polarography, IR, HPLC, GC, and gel chromatography to analyze the surfactant solutions.
He is an expert in surfactant applications in clinical, immunological and hematology reagents. He was involved with the development of reagent formulations for use on automated analyzers. A snapshot of some of the important contributions in the use of surfactants in clinical, immuno- and hematology reagents that Expert has made during his 25 years in the field are described below.
The aforementioned projects have benefited by Expert’s involvement due to his broad background of surface active agents in the clinical testing sciences. He possesses exceptional knowledge and skills in the application of surfactants and reagent formulations designed to improve reagent performance, interfacial interactions and system hydraulic performance. By virtue of extending the science of surfactants to practical applications in biological formulations and interfaces, Expert became an individual with unique knowledge and experience. Over the course of his professional career, he has gained significant experience in the troubleshooting of critical problems in clinical science.
In addition to Expert’s technical knowledge in the application of surfactants in clinical reagents, he has extensive experience in control system development. He has developed control systems for clinical chemistry methods, as well as product development requirements (PDRS). He has analyzed R&D method performance data to develop specifications, test methods and shelf life claims. He is familiar with product development under GMP and the PACE® (Product And Cycle-Time Excellence) guidelines.
Expert has devoted his time to working on free T4 immunoassay development using a nonionic surfactant, which resulted in improved precision of an assay for immuno auto-analyzers.He has also researched latex micro-particles immunoassays for TDM- attached antibodies to detect the presence of therapeutic drugs in serum samples. Expert has contributed to work on liposome-based assays suitable for flow systems. He introduced new surfactants to maintain the integrity of liposome in flow systems.He made a significant contribution to the clearing agent for lipemic serum samples -- Expert developed a reagent to improve optical measurement viability.In the area of cholesterol/triglyceride reagents (surfactant-enhanced enzyme), he improved reagents to reduce cost.
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 1970 | Degree: Ph.D. | Subject: Chemical Engineering (Biosurfactant Chemistry) | Institution: Indian Institute of Science [Bangalore, India] |
| Year: 1967 | Degree: Ph.D. | Subject: Physical Chemistry | Institution: University of Roorkee [Roorkee, India] |
| Year: 1963 | Degree: M.S. | Subject: Surface and Colloid Chemistry | Institution: Aligarh University [Aligarh, India] |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 2001 to Present | Employer: Undisclosed | Title: Independent Consultant | Department: |
Responsibilities:Available upon request. |
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| Years | Employer | Title | Department |
| Years: 1990 to 2001 | Employer: Bayer Corporation | Title: | Department: |
Responsibilities:While with Bayer, expert was responsible for modifying immuno reagents for Bayer autoanalyzers. |
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| Years | Employer | Title | Department |
| Years: 1982 to 1990 | Employer: Revlon | Title: | Department: |
Responsibilities:At Revlon, he was responsible for the development of liposome- and latex-based immuno reagents for HIV and TDM. |
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| Years | Employer | Title | Department |
| Years: 1976 to 1982 | Employer: | Title: Senior Scientist | Department: |
Responsibilities:Expert was responsible for modifying clinical chemistry reagents for SMA, SMAC and Chem-1. |
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| Years | Employer | Title | Department |
| Years: 1974 to 1976 | Employer: | Title: Research Associate | Department: |
Responsibilities:Expert worked on tautomeric catalysis and hollow fiber enzyme reactors under an NIH grant. |
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| Years | Employer | Title | Department |
| Years: 1973 to 1974 | Employer: | Title: Research | Department: |
Responsibilities:He studied the electrostatic effect on dyes in surfactant solutions. |
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| Years | Employer | Title | Department |
| Years: 1970 to 1973 | Employer: | Title: Group Leader | Department: |
Responsibilities:Expert developed theories for emulsions, microemulsions and foams using surfactant phase diagrams. |
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Career Accomplishments
| Associations / Societies |
|---|
| Expert belongs to the American Chemical Society (ACS), American Association of Clinical Chemistry (AACC), Westchester Chemical Society, American Oil Chemist Society [North Eastern Section], and the Indian Association of Clinical Chemists. |
| Professional Appointments |
|---|
| He served as Chairman and Board of Directors of the American Chemical Society (Westchester), the American Oil Chemist Society and the Indian Association of Clinical Chemists. Expert has also served as Chairman of the "New Horizons In Surfactant Chemistry Symposium," American Oil Chemist Society, North East Division. |
| Awards / Recognition |
|---|
| He received the Bayer Science Achievement Award, CSIR scholarships of India, a Swedish Academy of Sciences Scholarship, a NIH Scholarship and Grant for Research, and Technicon Patent Awards. |
| Publications and Patents Summary |
|---|
| He has eight patents and 27 publications in different fields of surface and colloid chemistry. |
Language Skills
| Language | Proficiency |
|---|---|
| Hindi | Expert is proficient in the Hindi language. |
| Urdu | He is proficient in Urdu. |
| German | He is knowledgable of technical German. |
Fields of Expertise
immunochemistry, immunodiagnostics, immunoassay, enzyme immunoassay, enzyme-linked immunosorbent assay, clinical laboratory, clinical laboratory equipment, antibody, antigen-antibody interaction, non-ionic surfactant, defoaming, detergent, colloid and interface chemistry, contact angle measurement, interfacial tension measurement, reagent, surfactant chemistry, clinical chemistry, blood chemistry, surface chemistry, polymer surface chemistry, block copolymer surfactant application, micelle, chemical research and development, epitope, cosurfactant, cationic surfactant, Western blotting, anionic surfactant, detergent testing, latex emulsion, immunoglobulin G, reagent manufacturing, cationic detergent, anionic detergent, clinical study, enzyme inhibitor, enzyme detergent, fluorochemical, colloidal suspension, cationic dye, emulsion breaking, clinical trial design, surface tension control, biophysical chemistry, polymeric surfactant, interfacial water, emulsion coating material, poloxamer, lipid biochemistry, polyclonal antibody, hydrotrope, propylene oxide, ethylene-propylene block copolymer, gel chemical reaction, bioorganic chemistry, contact angle, enzyme purification, colloid technology, instrumental analysis, clinical research management, clinical research, immunofluorescence laboratory blood analyzer, immunofluorescence, albumin, analytical biochemistry, applied chemistry, medical diagnostics, interfacial tension, clinical protocol, biological response modifier, surface tension measurement, immunocytochemistry, drug analysis, liquid crystal material, emulsifier, chemical analysis separation, immunohistochemistry, drug blood level determination, emulsion (mixture), degreasing agent, chemical reagent, lung surfactant, food surfactant, chemical cleaning, protein antigen, clinical immunology, biochemical engineering, AIDS, surfactant, surface tension, physical biochemistry, organic chemistry, on-line chemical analysis, monoclonal antibody, lecithin, immunology, immunoglobulin, health care system, gel, froth flotation, flocculating agent, enzymology, emulsion polymerization, drug bioavailability, dispersion technology, diagnostics, colorimetry, chemistry, catalyst, catalysis, biosurfactant, chemical autoanalysis, antigen, antifoaming agent, anionic polymerization, analytical chemistry