Expert Details

Molecular Biology, Genetics, Cancer Biology, Radiation Biology, Genetic Engineering

ID: 731251 Colorado, USA

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Expert was continuously funded 1990-2018 by the NIH (NCI, NIGMS), typically as PI of 2-3 concurrent R01 grants, and is currently funded by the American Lung Association (2020-2022). Expert published more than 130 reports of original research and reviews that have been cited more than 6000 times (h index = 45) and averaging more than 300 citations annually over the past decade. Publications have appeared in top journals including Nature, Nature Structural and Molecular Biology, Molecular Cell, PNAS, Blood, Cancer Research, Molecular and Cellular Biology, Oncogene, Nucleic Acids Research, and Genetics. He served for 8 years as Chair of the Department of Molecular Genetics and Microbiology in the University of New Mexico School of Medicine, a department with 17-18 faculty and a $6M annual budget. He was Director/co-Director of the UNM Cancer Center Cancer Biology program and in this role helped secure both P20 and P30 Cancer Center support grants. Expert led the CSU Department of Environmental and Radiological Health Sciences, with 40-42 faculty, and a $13M annual budget from 2008-2019 and continues to direct his research lab. Expert holds a patent (Site-Directed Mutagenesis of DNA) that was licensed by three biotechnology companies. Expert has more than 30 years of experience in genetic engineering, and more than 25 years of experience in the fields of cancer biology, eukaryotic DNA repair, and cell signaling responses to DNA damage including replication stress responses. He is a leader in the field of chromatin regulation of DNA repair. His most recent NIH grant focused on molecular mechanisms of cell response to chemotherapeutic agents, largely using molecular genetic approaches. He has served on numerous NIH grant review panels and grant review panels for foreign funding agencies. He led studies of the biological effects of heavy ion (carbon) radiation at the Japan National Institute of Radiological Sciences in his role as NIRS Distinguished Foreign Scientist, and led efforts to transfer US patients to Japan for carbon ion radiotherapy, building a consortium involving CSU, the University of Colorado Denver School of Medicine and Cancer Center, Children's Hospital.

He consulted with a law firm in Washington, DC on a biotechnology patent law dispute; with a South Carolina law firm on an oncology malpractice suit; and with a Canadian law firm on a low-dose radiation exposure suit. He has served as Science Advisory Board member, KromaTid, Inc. KromaTid is a start up biotechnology firm that manufactures molecular cytogenetic and custom gene tracking assays to discover, detect and diagnose the widest range of disease causing mutations – including DNA sequence inversions and translocations – in a single test. Based on Directional Genomic Hybridization™ (dGH), KromaTiD assays generate sequence, location and orientation data from single cells, making them ideal for mixed cell population studies. He has served as member of Scientific Advisory Boards for Employer, University of Texas Medical Branch NASA Specialized Center of Research program, Emory University, and Yale University.

Education

Year Degree Subject Institution
Year: 1983 Degree: PhD Subject: Biochemistry Institution: University of Colorado, Boulder
Year: 1978 Degree: BA Subject: Biochemistry Institution: University of California Santa Barbara

Work History

Years Employer Title Department
Years: 2008 to Present Employer: Undisclosed Title: Professor (former Department Head) Department: Environmental and Radiological Health Sciences
Responsibilities:
For 11 years (2008-2019) managed a diverse faculty with 40-42 members in six sections (Radiation Cancer Biology, Veterinary Radiation Oncology, Veterinary Radiology, Radiation Protection and Measurement/Health Physics, Toxicology, Environmental Health Epidemiology, Industrial Hygiene), overseeing clinical radiology and radiation oncology programs, bachelors, masters, and doctoral degree programs. Expert directed an NIH-funded research lab with 6-8 members from 1990-2018, and his lab is currently funded by the American Lung Association (2020-2022).
Years Employer Title Department
Years: 1996 to 2008 Employer: University of New Mexico School of Medicine Title: Assoc Professor/Professor/Chair Department: Department of Molecular Genetics and Microbiology
Responsibilities:
Directed NIH-funded research lab focused on DNA repair and cancer biology, and for 8 years Chaired the Department of Molecular Genetics and Microbiology with 17-18 faculty focused on research in infectious disease, virology, cell biology and cancer biology. Also led/co-led the Cancer Biology section of the NCI-designated UNM Cancer Center.
Years Employer Title Department
Years: 1990 to 1996 Employer: Harvard University School of Public Health Title: Assistant/Associate Professor Department: Cancer Biology (Radiation Biology section)
Responsibilities:
Directed NIH-funded research lab

Additional Experience

Expert Witness Experience
Expert witness/provided deposition in biotechnology patent case (gene therapy) for law firm in Washington, DC. Expert provided testimony in oncology malpractice suit in South Carolina. Expert provided testimony in low-dose radiation exposure suit in Toronto, Canada.

Career Accomplishments

Associations / Societies
Genetics Society of America (1991-present), American Association for Cancer Research (1998-2010), Radiation Research Society (1994-present)
Awards / Recognition
Endowed Chair, UNM School of Medicine, 2008 (declined, relocated to Employer)
Distinguished Foreign Scientist, Japan National Institute of Radiological Science (2011-2018)
Exceptional Mentor Award, Jack and June Richardson Honors Thesis program (2013)
Diploma of Excellence, Gheorghe Asachi Technical University of Iaşi, Romania (2018)
Publications and Patents Summary
Published more than 120 original articles, more than 20 review articles in DNA repair, cell biology and cancer biology fields, has one patent, edited or co-edited 6 volumes (3 on DNA damage and repair, 3 technical manuals).

Fields of Expertise

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