Expert Details

Medicinal Chemistry, Drug Discovery, Organic Chemistry, Antibody-Drug Conjugates

ID: 731784 California, USA

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Accomplished project leader with strong experience as R & D medicinal chemist in advancing projects from inception to Phase I clinical trials in ocular, inflammation, diabetes and neuroscience areas. Skilled in medicinal chemistry, organic chemistry, small molecule and peptide lead optimization, bioconjugation, and antibody drug conjugates. Expertise in leading cross-functional teams for drug discovery projects. Advanced three projects to Phase I and three projects to candidate nomination stage.

Core competencies include: Oncology, neuroscience, diabetes research. Project leader in matrix environment. Managed and directed chemistry projects at CROs. Co-led Portfolio Optimization Committee and launched new projects. Modern synthetic & medicinal chemistry. Drug discovery and biology knowledge. Small molecule and peptide medicinal chemistry. Outsourcing Project Management and External Relationship Development.


Worked with Ignyta on their chemistry needs (2013)Currently working with two biotech companies (2014-- ).

Education

Year Degree Subject Institution
Year: 1989 Degree: Ph.D. Subject: Medicinal Chemistry Institution: The University of Kansas

Work History

Years Employer Title Department
Years: 2008 to 2013 Employer: Pfizer Title: Senior Principal Scientist Department: Chemistry, CovX division
Responsibilities:
He identified new targets and launched new drug discovery projects. He led a multi-disciplinary team of scientists to advance projects to Phase I. He was a project leader for diabetes and long acting human growth hormone projects. He was responsible for developing new peptide delivery platform technology
Years Employer Title Department
Years: 2006 to 2008 Employer: TargeGen Title: Principal Scientist IV Department: Medicinal Chemistry
Responsibilities:
He advanced projects to Phase I by working with scientists in ocular and oncology area
Years Employer Title Department
Years: 1994 to 2006 Employer: Celgene Title: Group Leader Department: Medicinal Chemistry
Responsibilities:
He was senior chemist on AP-1 NFkB, IKK2 projects
He was project leader for Neuroscience and PKC theta projects
He was head of compound library generation group and compound library management and distribution group
Years Employer Title Department
Years: 1992 to 1994 Employer: La Jolla Pharmaceuticals Title: Scientist II Department: Chemistry
Responsibilities:
Lead chemist and worked on LJP-394, a drug for treating systemic lupus erythematosus.

Career Accomplishments

Associations / Societies
A member of American Chemical Society
A member of American peptide society
Licenses / Certifications
Currently enrolled in Project Management Certificate program at UCSD, Cornerstones of Management 1(A) - Delivering Results
Publications and Patents Summary
27 papers, 27 posters and oral presentations, 18 patents (applications and issued).

Fields of Expertise

drug discovery, medicinal chemistry, oncology, biology, neuroscience, project management, organic chemistry, chemistry, computational chemistry, molecule, chemotherapeutic drug, computer-aided drug design, drug development, fluorine chemistry, heterocyclic chemistry, high-throughput screening (drug discovery), prodrug, protein drug, rational drug design, analytical chemistry instrument, bioorganic chemistry, applied organic chemistry, analytical chemistry

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