Intellex Acquires Expert by Big Village

We're thrilled to announce that Intellex has acquired Expert by Big Village, effective March 22, 2024. This strategic move enhances our capabilities and strengthens our commitment to delivering exceptional solutions to our customers.

Stay tuned for more updates on how this acquisition will benefit our clients and experts.

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Expert Details

Lipases, Biointerfaces, Instrumentation, Interaction of Drugs and Proteins with Lipids, Monolayers

ID: 107690 Minnesota, USA

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LIPASES. Expert has spent most of his scientific career studying the regulation of lipases and other enzymes which function at oil-water interfaces. The emphasis of his work has been placed upon studying the role of lipid-lipid and lipid-protein interactions in the control of lipolysis at the molecular level. Lipids with which he has been particularly interested are lecithin, diacylglycerol, fatty acid, and cholesterol.

CHOLESTEROL ESTERASES. As a part of his study of lipases in general, Expert has devoted considerable effort to the study of cholesterol esterases. He notes that these are important enzymes in mammalian cholesterol homeostasis. The mammalian form most studied by Expert is that which belongs to the cholinesterase gene family. This is also known as bile-salt-stimulated lipase, lysophospholipase, carboxylester lipase, sterol ester hydrolase, and non-specific lipase.

ADSORPTION. Expert has extensive expertise in studying enzyme, peptide and drug adsorption to lipid-water interfaces. He notes that this has been necessitated by his lipase interest because lipases must adsorb to the lipid-water interface before they can act on substrates in it. The emphasis of his work on adsorption has been the retention of catalytic activity. Examples of this include the lack of protein denaturation and the role of the 2-dimensional organization of lipids in regulating protein adsorption. His recent focus has been on the application of percolation theory to the regulation of lipase adsorption and catalysis.

MONOMOLECULAR FILMS. Expert has made extensive use of monolayer techniques as a model lipid-water interface for studying lipase adsorption and catalysis. For analyzing such data, he has developed mathematical algorithms to characterize the surface potential-surface pressure-area characteristics of mixtures of lipids in monomolecular films. Lipids of interest to him have been phospholipids, acylglycerols, fatty acids, and cholesterol esters. Expert has developed automated instrumentation to facilitate the study of lipid-lipid and lipid-protein interactions in monomolecular films. He has emphasized the detection and elimination of surface-active impurities in this work. His goal in doing so has been to insure the accuracy and precision of his data.


Education

Year Degree Subject Institution
Year: 1971 Degree: PhD Subject: Biochemistry, Institution: Michigan State University
Year: 1966 Degree: BA Subject: Chemistry, Institution: DePauw University

Work History

Years Employer Title Department
Years: 1981 to Present Employer: Undisclosed Title: Undisclosed Department: The Hormel Institute
Responsibilities:
Responsible for creating, funding executing research projects on lipid-lipid interactions as regulators of the interactions of enzymes, peptides and drugs with membranes
Years Employer Title Department
Years: 1977 to 1981 Employer: University Of Minnesota, The Hormel Institute Title: Undisclosed Department: The Hormel Institute
Responsibilities:
Available upon request.
Years Employer Title Department
Years: 1973 to 1977 Employer: Undisclosed Title: Assistant Professor Department: Undisclosed
Responsibilities:
Available upon request.
Years Employer Title Department
Years: 1999 to Present Employer: Undisclosed Title: President Department: Undisclosed
Responsibilities:
Developing an marketing software, consulting and instrumentation in the area of biophysical surface chemistry

Career Accomplishments

Associations / Societies
Expert is a member of the American Chemical Society, the American Society of Biological Chemists, the Council on Atherosclerosis of the American Heart Association, the American Association for the Advancement of Science, and the Biophysical Society. In addition to his primary appointment, Expert is an Associate Faculty member of the self assembly processes group of the Employer's Center for Interfacial Engineering.
Professional Appointments
He is on the Editorial Board of the Journal of Lipid Research. In addition, he has been an Established Investigator of the American Heart Association.
Publications and Patents Summary
He has published over 60 technical papers.

Language Skills

Language Proficiency
French and German Expert reads French and German.

Fields of Expertise

adsorption, cholesterol esterase, lipase, monomolecular film, enzyme regulation, computerized analytical instrumentation design, diacylglycerol, fluorescence measurement, surface chemistry, protein purification, phospholipase, lipid, lecithin, fluorescence spectroscopy, fatty acid, computerized analytical instrumentation, cholesterol

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