Expert Details
Heterogeneous Catalytic Hydrogenation for the Production of Fine Chemicals
ID: 729596
Switzerland
(1) Infrastructure (laboratory and plant instrumentation incl. data acquisition, instrument control and data management) needed for catalytic hydrogenation investigations
(2) Selection and use of appropriate tools and methods in the development of catalytic processes (appropriate use of high throughput instruments, state of the art chemical development, state of the art determination of basic data for safe and reliable scale up)
(3) Development of new processes (chemical system selection, basic data evaluation, kinetics)
(4) Scale up of catalytic hydrogenations (micro- and macrokinetics, thermodynamics, safety)
(5) Assessment of probability of postulated reactions along with route scouting and exploratory investigations
(6) Analysis, assessment and improvement of current plant processes
(7) Catalyst deactivation measurement, catalyst reactivation and catalyst recycling
(8) Safety and risk analysis of catalytic hydrogenations
(9) Improvement of economy and ecology of catalytic processes
(10) particular experience in the selective hydrogenation of alkynes to alkenes, nitriles to amines, phenols to cyclohexanones, stereoselective hydrogenation of substituted aromatic compounds, diastereoselective hydrogenations, chemoselective hydrogenations of multifunctional compounds, selective hydrogenation of nitrate to hydroxylamine, selective hydrogenation of halogensubstituted nitroaromatics to the corresponding halogensubstituted anilines, hydrogenation of sorbitol, hydrogenation/rearrangement of nitroaromatics to para-aminophenol compounds, selective partial hydrogenation of nitroaromatics to the corresponding hydroxylamines
(11) particular experience in the oxidative dehydrogenation of primary alcohols to carboxylic acids
Expert has specific know how in micro- and macrokinetics, determination of gas/liquid transport coefficients, measurement of gas partial pressures in the liquid (also in situ during reactions)
Expert has excellent know-how in the development of highly economic, ecologic, safe, robust and scalable hydrogenation processes.
He consulted fine chemicals and pharmaceuticals custom manufacturer in (1) establishing a new state of the art hydrogenation laboratory including infrastructure, (2) coaching within R&D as well as production, (3) analysis and significant improvement of current plant processes, (4) management of specific projects. selection of appropriate equipment for the development of hydrogenation processes public and in house courses on theory and practice of catalytic hydrogenation for the production of fine chemicals and pharmaceuticals (comprehensive course on all important aspects of hydrogenation technology) under the auspices of development of various large scale hydrogenation processes trouble shooting of catalytic hydrogenation processes
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 1978 | Degree: PhD | Subject: Chemistry | Institution: University of Zuerich |
| Year: 1979 | Degree: Postdoctoral Studies | Subject: Chemistry | Institution: University of Cambridge |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 2005 to Present | Employer: Undisclosed | Title: Director | Department: Consulting |
Responsibilities:Independent consultant on all aspects of catalytic hydrogenation. |
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| Years | Employer | Title | Department |
| Years: 2004 to 2006 | Employer: Self Employed | Title: Scientific Expert | Department: |
Responsibilities:Development of various catalytic hydrogenation processes for the production of pharmaceuticals, liquid crystals, fine chemicals |
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| Years | Employer | Title | Department |
| Years: 2001 to 2003 | Employer: DSM Nutritional Products | Title: Scientific Expert | Department: R&D Heterogeneous Catalysis and Reaction Engineering |
Responsibilities:Development of new highly economic processes for the production of vitamins development of a process for the selective hydrogenation of nitrate to hydroxylamine |
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| Years | Employer | Title | Department |
| Years: 1988 to 2000 | Employer: Roche | Title: Scientific Specialist | Department: R&D |
Responsibilities:Chemical process development of API and of vitamins |
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| Years | Employer | Title | Department |
| Years: 1980 to 1987 | Employer: Roche | Title: Laboratory Manager | Department: Central research |
Responsibilities:Development of high throughput methods for organic chemistry |
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International Experience
| Years | Country / Region | Summary |
|---|---|---|
| Years: 2005 to Present | Country / Region: Switzerland, Belgium, China, United Kingdom | Summary: Consulting on development of economic, ecologic, robust, scalable and safe hydrogenation processes |
Career Accomplishments
| Awards / Recognition |
|---|
| Swiss Chemical Society: Sandmeyer Award and Sandmeyer Award |
| Publications and Patents Summary |
|---|
| 19 Publications, 2 contributions in Monographs, 2 lectures (at Swiss and Italian Chemical Society), 6 posters at Congresses, 4 patents |
Additional Experience
| Training / Seminars |
|---|
| Regular courses on heterogeneous catalytic hydrogenation organized by scientific update |
Language Skills
| Language | Proficiency |
|---|---|
| German (Mother Language) | |
| English | Fluent, written and spoken |
| French | Good school knowledge, but not trained |
| Italian | Good school knowledge, but not trained |
Fields of Expertise
aliphatic ketone, alkene, alkyne, alkyne catalytic hydrogenation, ammonium nitrate, aromatic compound, aromatic compound catalytic hydrogenation, catalysis, catalytic hydrogenation, catalytic oxidation, dehalogenation, deprotection, haloaromatic amine, hydrogenation, hydrogenolysis, ketone catalytic hydrogenation, nitrate reduction, nitro compound catalytic hydrogenation, nitroso compound catalytic hydrogenation, selective catalytic reduction, selective catalytic reduction catalyst, Arrhenius equation, heterogeneous reaction kinetics, reductive alkylation, bimetallic hydrogenation catalyst, hydrogenation catalyst, dehydrogenation, Raney nickel, alkene catalytic hydrogenation, catalyst reactivity, nitrile hydrogenation