Expert Details
Biophysics, Fragment Screening, Model Membranes, and Scientific Communication
ID: 733869
United Kingdom
Throughout her scientific education, Expert has had the opportunity to explore a broad spectrum of methods in
biology, physics and chemistry to characterize protein-ligand interactions. She applied and maintained
various biophysical methods like SPR but also methods like NMR, ITC, infrared reflection absorption
spectroscopy, fluorescence spectroscopy, dynamic light scattering (DLS) and fluorescence correlation spectroscopy (FCS), and fluorescence microscopy techniques such as confocal microscopy, total internal refelection fluorescence (TIRF) microscopy and two-photon microscopy.
Expert is routinely consulting collaborators regarding their biophysical appications, fragment screening and model membrane systems.
In addition, she has a strong background concerning the establishment of new biophysical assays.
Expert is currently using SPR, ITC and NMR assays to study protein-small molecule interactions in
addition to conducting fragment screens working with cancer related targets including small GTPases.
During her postdoctoral studies, she was working on the development of a new SNARE-mediated fusion assay
measuring synaptic vesicle fusion to a freestanding membrane in vitro on a single vesicle level. Before
this time, she focused on the setup of new biophysical assays especially using SPR, but also other above
mentioned techniques for the analysis of kinetics and conformational dynamics of protein-membrane
and protein-protein and drug interactions in the field of Ras GTPases and amyloids.
Expert's working attitude comprises high commitment, consistency and a strong identification with her
projects. She has been awarded a postdoctoral fellowship of the German Research Foundation, as well as several poster prizes at international conferences. She is able to produce commendable results working individually and as part of a multidisciplinary team, as depicted in her publication record.
Expert has the ability to organise and take on leadership roles -- as, for example, she is currently organizing and consulting collaborative fragment screens. She has organized a scientific symposium and led on a project for the independent establishment of a cell laboratory during her dissertation.
Expert is routinely consulting her collaborators concerning the following topics:
Preparation and execution of fragment-based screening.
Biophysical methods
Making and presenting of scientific posters and talks, writing of scientific proposals
Model membranes
Education
Year | Degree | Subject | Institution |
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Year: 2010 | Degree: Dr. rer. nat. | Subject: Biophysical Chemistry | Institution: TU Dortmund (Germany) |
Year: 2006 | Degree: Master of Science (M. Sc.) | Subject: Molecular Life Science | Institution: University of Lübeck (Germany) |
Year: 2004 | Degree: Bachelor of Science (B. Sc.) | Subject: Molecular Biotechnology | Institution: University of Lübeck (Germany) |
Work History
Years | Employer | Title | Department |
---|---|---|---|
Years: 2017 to Present | Employer: Undisclosed | Title: Principal Scientific officer | Department: Drug Discovery Programme |
Responsibilities:Organisation, execution and follow-up of fragment screens against cancer-related target. |
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Years | Employer | Title | Department |
Years: 2015 to 2017 | Employer: CRUK Beatson Institute | Title: Senior Scientific officer | Department: Drug Discovery Programme |
Responsibilities:Organisation, execution and follow-up of fragment screens against cancer-related target. |
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Years | Employer | Title | Department |
Years: 2012 to 2015 | Employer: École normale supérieure (France) | Title: Postdoctoral associate | Department: Laboratoire de Physique Statistique |
Responsibilities:Biophysical studies of SNARE-mediated membrane fusion. |
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Years | Employer | Title | Department |
Years: 2010 to 2015 | Employer: Yale University (USA) | Title: Postdoctoral associate / fellow | Department: Cell Biology |
Responsibilities:Biophysical studies of SNARE-mediated membrane fusion. |
International Experience
Years | Country / Region | Summary |
---|---|---|
Years: 2015 to 2017 | Country / Region: United Kingdom | Summary: Principal / senior scientific officer in the Drug Discovery Programme at the Cancer Research UK Beatson Institute (UK) |
Years: 2012 to 2015 | Country / Region: France | Summary: Postdoctoral associate at the “Laboratoire de Physique Statistique” de l'École normale supérieure (France), Topic: “Biophysical studies of SNARE-mediated membrane fusion” |
Years: 2010 to 2015 | Country / Region: USA | Summary: Postdoctoral associate/fellow at the “Department of Cell Biology”, Yale University (USA), Topic: “Biophysical studies of SNARE-mediated membrane fusion” |
Years: 2010 to 2015 | Country / Region: Netherlands | Summary: Visiting scientist at the Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute in Groningen (The Netherlands) Topic: “Creation of pore spanning membranes containing transmembrane proteins” |
Years: 2007 to 2007 | Country / Region: USA | Summary: Visiting scientist at the “Laboratory for Fluorescence Dynamics” in Irvine, California (USA) Topic: “Fluorescence study of Ras membrane interactions” |
Years: 2005 to 2005 | Country / Region: Czech Republic | Summary: Internship in the “Department of Food Preservation” at the Institute of Chemical Technology in Prague (Czech Republic) Topic: “Migration of Natamycin” |
Career Accomplishments
Associations / Societies |
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International Max Planck Research School in Chemical Biology at the Max Planck Institute of Molecular Physiology in Dortmund (Germany) Biophysical Society Scottish NMR user group German Bunsen Society |
Awards / Recognition |
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CCPN conference 2017 (poster prize) 3rd NovAliX Conference 2016 (poster prize) Scottish NMR Users Group meeting 2016 (poster prize) German Research Foundation (DFG) (Germany) (full time fellow) (2011-2012) |
Publications and Patents Summary |
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Expert has authored or co-authored 5 refereed articles. |
Language Skills
Language | Proficiency |
---|---|
German | Native |
English | Fluent |
French | Basic |
Fields of Expertise
cancer research, analytical research, phospholipid, intermolecular interaction, nuclear magnetic resonance, high-throughput screening (drug discovery), surface plasmon, total internal reflection, confocal microscopy, fluorescence microscopy, drug discovery, cell membrane biophysics, biophysics, organization, proposal writing, presentation quality